It is a common misconception that eating saturated dietary fat will increase inflammation.
This misconception comes from the observation that a high level of circulating saturated free fatty acids (SFFA) is causing inflammation and, in turn, insulin resistance (IR), via lipotoxicity (DAGs) and ceramides. This observation is correct, but the proposition that the elevated level of SFFAs come from dietary saturated fat is wrong.
An increase in the level of circulating FFAs happens when adipocytes become IR, thus leaking FFAs (HSL being affected) or being unable to uptake FFAs properly once LPL acts on lipoproteins.
Adipocytes often become IR due to overeating, but it doesn’t matter what one eats. If there’s chronic caloric excess, one gets IR adipocytes and an increased level of circulating FFAs.
Therefore, a high level of circulating SFFAs do create inflammation, but the cause is overeating, not dietary saturated fat in particular.
It is true though that in an altered metabolic state (being overweight), MUFAs and PUFAs have a neutral or beneficial effect on inflammation. So if one eats too much, he should rather reduce/avoid saturated fats, but even better, one should avoid chronically eating too much and then saturated fat is not an issue.
*Omega 3 & 6 should be balanced properly for a positive effect from PUFAs.